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Echocardiography 5 minutes before starting  


Derliz Mereles comes from Asunción, Paraguay, and is since 1993 research fellow, as well as since 2009 Head of the Echocardiography Laboratory of the Cardiology Department of the University Hospital of Heidelberg.

He studied medicine in Paraguay. He attained in 1987 the titel "Doctor en Medicina y Cirugía" from the National University of Asunción and in 2004 the titel "Doctoris medicinae" from the Ruprecht-Karls-University Heidelberg. The titel Specialist in Cardiology was granted him from the Paraguayan Medical Association in 1999.

With this tutorial, he would like to hand on his many years of experience in the field of echocardiography.

Scientific work and publications

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Giusca S, Mereles D, Ochs A, Buss S, André F, Seitz S, Riffel J, Fortner P, Andrulis M, Schönland S, Katus HA, Korosoglou G.
Incremental value of cardiac magnetic resonance for the evaluation of cardiac tumors in adults: experience of a high volume tertiary cardiology centre.
Int J Cardiovasc Imaging. 2017;33:879-888.

Ochs MM, Fritz T, André F, Riffel J, Mereles D, Müller-Hennessen M, Giannitsis E, Katus HA, Friedrich MG, Buss SJ.
A comprehensive analysis of cardiac valve plane displacement in healthy adults: age-stratified normal values by cardiac magnetic resonance.
Int J Cardiovasc Imaging. 2017;33:721-729.


Ochs MM, Riffel J, Kristen AV, Hegenbart U, Schönland S, Hardt SE, Katus HA, Mereles D, Buss SJ.
Anterior Aortic Plane Systolic Excursion: A Novel Indicator of Transplant-Free Survival in Systemic Light-Chain Amyloidosis.
J Am Soc Echocardiogr. 2016;29:1188-1196.

Kovacs G, Dumitrescu D, Barner A, Greiner S, Grünig E, Hager A, Köhler T, Kozlik-Feldmann R, Kruck I, Lammers A, Mereles D, Meyer A, Meyer FJ, Pabst S, Seyfarth HJ, Sinning C, Sorichter S, Stähler G, Wilkens H, Held M. [Clinical classification and initial diagnosis of pulmonary hypertension: recommendations of the Cologne Consensus Conference 2016].
Dtsch Med Wochenschr. 2016;141(S01):S10-S18.

Kallenberger SM, Schmid C, Wiedmann F, Mereles D, Katus HA, Thomas D, Schmidt C. A Simple, Non-Invasive Score to Predict Paroxysmal Atrial Fibrillation.
PLoS One. 2016;11:e0163621.
open source

Amr A, Kayvanpour E, Sedaghat-Hamedani F, Passerini T, Mihalef V, Lai A, Neumann D, Georgescu B, Buss S, Mereles D, Zitron E, Posch AE, Würstle M, Mansi T, Katus HA, Meder B. Personalized Computer Simulation of Diastolic Function in Heart Failure.
Genomics Proteomics Bioinformatics. 2016;14:244-52.
open source

Vermeer AM, Lodder EM, Thomas D, Duijkers FA, Marcelis C, van Gorselen EO, Fortner P, Buss SJ, Mereles D, Katus HA, Wilde AA, Bezzina CR, Boekholdt SM, Schweizer PA, Christiaans I. Dilation of the Aorta Ascendens Forms Part of the Clinical Spectrum of HCN4 Mutations.
J Am Coll Cardiol. 2016;67:2313-5.
open source

Mereles D, Aurich M, Greiner S, Riffel J, Buss SJ, Kristen AV, Katus HA.
Diagnosis of cardiac involvement in systemic amyloidosis by state-of-the-art echocardiography: where are we now?.
Expert Opin on Orphan Drugs. 2016, DOI:10.1080/21678707.2016.1179573.
open source

Aurich M, Keller M, Greiner S, Steen H, Aus dem Siepen F, Riffel J, Katus HA, Buss SJ, Mereles D.
Left ventricular mechanics assessed by two-dimensional echocardiography and cardiac magnetic resonance imaging: comparison of high-resolution speckle tracking and feature tracking.
Eur Heart J Cardiovasc Imaging. 2016 Mar 24. pii: jew042. [Epub ahead of print]


Chaves G, Brítez N, Maciel V, Klinkhof A, Mereles D.
[Prevalence of cardiovascular risk factors in an urban ambulatory adult population: AsuRiesgo study, Paraguay].
Rev Panam Salud Publica. 2015;38:136-43.
open source

Sedaghat-Hamedani F, Kayvanpour E, Frankenstein L, Mereles D, Amr A, Buss S, Keller A, Giannitsis E, Jensen K, Katus HA, Meder B.
Biomarker Changes after Strenuous Exercise Can Mimic Pulmonary Embolism and Cardiac Injury-A Metaanalysis of 45 Studies.
Clin Chem. 2015;61:1246-55.

Kayvanpour E, Mansi T, Sedaghat-Hamedani F, Amr A, Neumann D, Georgescu B, Seegerer P, Kamen A, Haas J, Frese KS, Irawati M, Wirsz E, King V, Buss S, Mereles D, Zitron E, Keller A, Katus HA, Comaniciu D, Meder B.
Towards Personalized Cardiology: Multi-Scale Modeling of the Failing Heart.
PLoS One.2015;10:e0134869.
open source

Rivinius R, Helmschrott M, Koch V, Sedaghat-Hamedani F, Fortner P, Darche FF, Thomas D, Ruhparwar A, Schmack B, Karck M, Akhavanpoor M, Erbel C, Gleissner CA, Buss SJ, Mereles D, Ehlermann P, Katus HA, Doesch AO.
Constrictive Pericarditis in the Presence of Remaining Remnants of a Left Ventricular Assist Device in a Heart Transplanted Patient.
Case Rep Transplant. 2015;2015:372698.
open source

Hirschberg K, Reinhart M, Konstandin M, Uhlmann L, Katus HA, Mereles D.
Diagnostic and prognostic value of a novel cardiac calcification score for coronary artery disease by transthoracic echocardiography.
Int J Cardiol. 2015;190:332-4.

Dehnert C, Mereles D, Greiner S, Albers D, Scheurlen F, Zügel S, Böhm T, Vock P, Maggiorini M, Grünig E, Bärtsch P.
Exaggerated hypoxic pulmonary vasoconstriction without susceptibility to high altitude pulmonary edema.
High Alt Med Biol. 2015;16:11-7.

Chaves G, Britez N, Munzinger J, Uhlmann L, Gonzalez G, Oviedo G, Chaparro V, Achon O, Bruckner T, Kieser M, Katus HA, Mereles D.
Education to a Healthy Lifestyle Improves Symptoms and Cardiovascular Risk Factors - AsuRiesgo Study.
Arq Bras Cardiol. 2015;104:347-55.
open source

Bekeredjian R, Bodingbauer D, Hofmann NP, Greiner S, Schuetz M, Geis NA, Kauczor HU, Bryant M, Chorianopoulos E, Pleger ST, Mereles D, Katus HA, Korosoglou G.
The extent of aortic annulus calcification is a predictor of postprocedural eccentricity and paravalvular regurgitation: a pre- and postinterventional cardiac computed tomography angiography study.
J Invasive Cardiol. 2015;27:172-80.

Riffel JH, Keller MG, Aurich M, Sander Y, Andre F, Giusca S, Aus dem Siepen F, Seitz S, Galuschky C, Korosoglou G, Mereles D, Katus HA, Buss SJ.
Assessment of global longitudinal strain using standardized myocardial deformation imaging: a modality independent software approach.
Clin Res Cardiol. 2015;104:591-602.

Zylla MM, Pohlmeier M, Hess A, Mereles D, Kieser M, Bruckner T, Scholz E, Zitron E, Schweizer PA, Katus HA, Thomas D.
Prevalence of intracardiac thrombi under phenprocoumon, direct oral anticoagulants (dabigatran and rivaroxaban), and bridging therapy in patients with atrial fibrillation and flutter.
Am J Cardiol. 2015;115:635-40.

Riffel JH, Mereles D, Emami M, Korosoglou G, Kristen AV, Aurich M, Voss A, Schonland SO, Hegenbart U, Hardt SE, Katus HA, Buss SJ.
Prognostic significance of semiautomatic quantification of left ventricular long axis shortening in systemic light-chain amyloidosis.
Amyloid. 2015;22:45-53.

Li J, Franke J, Pribe-Wolferts R, Meder B, Ehlermann P, Mereles D, Andre F, Abdelrazek MA, Merten C, Schweizer PA, Becker R, Katus HA, Thomas D.
Effects of ß-blocker therapy on electrocardiographic and echocardiographic characteristics of left ventricular noncompaction.
Clin Res Cardiol. 2015;104:241-9.

Haas J, Frese KS, Peil B, Kloos W, Keller A, Nietsch R, Feng Z, Müller S, Kayvanpour E, Vogel B, Sedaghat-Hamedani F, Lim WK, Zhao X, Fradkin D, Köhler D, Fischer S, Franke J, Marquart S, Barb I, Li DT, Amr A, Ehlermann P, Mereles D, Weis T, Hassel S, Kremer A, King V, Wirsz E, Isnard R, Komajda M, Serio A, Grasso M, Syrris P, Wicks E, Plagnol V, Lopes L, Gadgaard T, Eiskjær H, Jørgensen M, Garcia-Giustiniani D, Ortiz-Genga M, Crespo-Leiro MG, Deprez RH, Christiaans I, van Rijsingen IA, Wilde AA, Waldenstrom A, Bolognesi M, Bellazzi R, Mörner S, Bermejo JL, Monserrat L, Villard E, Mogensen J, Pinto YM, Charron P, Elliott P, Arbustini E, Katus HA, Meder B.
Atlas of the clinical genetics of human dilated cardiomyopathy.
Eur Heart J. 2015;36:1123-35a.


Kovacs G, Pienn M, Grünig E, Mereles D, Claussen M, Dandel M, Dumitrescu D, Kruck I, Bruch L, Blindt R, Holt S, Sinn L, Sorichter S, Winkler J, Olschewski H.
[Modern imaging methods in the management of pulmonary hypertension].
Dtsch Med Wochenschr. 2014;139 Suppl 4:S121-5.

Greiner S, Jud A, Aurich M, Hess A, Hilbel T, Hardt S, Katus HA, Mereles D.
Reliability of noninvasive assessment of systolic pulmonary artery pressure by Doppler echocardiography compared to right deart catheterization: analysis in a large patient population.
J Am Heart Assoc. 2014;3:e001103 doi: 10.1161/JAHA.114.001103.
open source

Aurich M, André F, Keller M, Greiner S, Hess A, Buss SJ, Katus HA, Mereles D.
Assessment of left ventricular volumes with echocardiography and cardiac magnetic resonance imaging: real-life evaluation of standard versus new semiautomatic methods.
J Am Soc Echocardiogr. 2014 Aug 14. [Epub ahead of print]

Schweizer PA, Schröter J, Greiner S, Haas J, Yampolsky P, Mereles D, Buss SJ, Seyler C, Bruehl C, Draguhn A, Koenen M, Meder B, Katus HA, Thomas D.
The symptom complex of familial sinus node dysfunction and myocardial noncompaction is associated with mutations in the HCN4 channel.
J Am Coll Cardiol 2014;64:757–67.

Greiner S, Heimisch M, Aurich M, Heß JA, Katus HA, Mereles D.
Multiplane two-dimensional strain echocardiography for segmental analysis of right ventricular mechanics: New-RV study.
Clin Res Cardiol. 2014 May 16. [Epub ahead of print]

Buss SJ, Krautz B, Schnackenburg B, Abdel-Aty H, Santos MF, Andre F, Maertens MJ, Mereles D, Korosoglou G, Giannitsis E, Katus HA, Steen H.
Classification of diastolic function with phase-contrast cardiac magnetic resonance imaging: validation with echocardiography and age-related reference values.
Clin Res Cardiol. 2014;103:441-50.

Buss SJ, Schulz F, Mereles D, Hosch W, Galuschky C, Schummers G, Stapf D, Hofmann N, Giannitsis E, Hardt SE, Kauczor HU, Katus HA, Korosoglou G.
Quantitative analysis of left ventricular strain using cardiac computed tomography.
Eur J Radiol. 2014;83:e123-30.

Bikiri E, Mereles D, Voss A, Greiner S, Hess A, Buss SJ, Hofmann NP, Giannitsis E, Katus HA, Korosoglou G.
Dobutamine stress cardiac magnetic resonance versus echocardiography for the assessment of outcome in patients with suspected or known coronary artery disease. Are the two imaging modalities comparable?
Int J Cardiol. 2014;171:153-60.


Pleger ST, Schulz-Schönhagen M, Geis N, Mereles D, Chorianopoulos E, Antaredja M, Lewening M, Katus HA, Bekeredjian R.
One year clinical efficacy and reverse cardiac remodelling in patients with severe mitral regurgitation and reduced ejection fraction after MitraClip© implantation.
Eur J Heart Fail. 2013 Mar 19. [Epub ahead of print]

Haas J, Frese KS, Park YJ, Keller A, Vogel B, Lindroth AM, Weichenhan D, Franke J, Fischer S, Bauer A, Marquart S, Sedaghat-Hamedani F, Kayvanpour E, Köhler D, Wolf NM, Hassel S, Nietsch R, Wieland T, Ehlermann P, Schultz JH, Dösch A, Mereles D, Hardt S, Backs J, Hoheisel JD, Plass C, Katus HA, Meder B.
Alterations in cardiac DNA methylation in human dilated cardiomyopathy.
EMBO Mol Med. 2013;5:413-429.

Greiner S, André F, Heimisch M, Heß A, Steen H, Katus HA, Mereles D. Non-invasive quantification of right ventricular systolic function by echocardiography: a new semi-automated approach.
Clin Res Cardiol. 2013;102:229-235.


Buss SJ, Emami M, Mereles D, Korosoglou G, Kristen AV, Voss A, Schellberg D, Zugck C, Galuschky C, Giannitsis E, Hegenbart U, Ho AD, Katus HA, Schonland SO, Hardt SE.
Longitudinal left ventricular function for prediction of survival in systemic light-chain amyloidosis: incremental value compared with clinical and biochemical markers.
J Am Coll Cardiol. 2012;60:1067-1076.

Mansi T, Mihalef V, Sharma P, Georgescu B, Zheng X, Rapaka S, Kamen A, Mereles D, Steen H, Meder B, Katus H, Comaniciu D. Data-driven computational models of heart anatomy, mechanics and hemodynamics: An integrated framework.
Biomedical Imaging (ISBI), 2012 9th IEEE International Symposium.
open source

Kristen AV, Lehrke S, Buss S, Mereles D, Steen H, Ehlermann P, Hardt S, Giannitsis E, Schreiner R, Haberkorn U, Schnabel PA, Linke RP, Röcken C, Wanker EE, Dengler TJ, Altland K, Katus HA.
Green tea halts progression of cardiac transthyretin amyloidosis: an observational report.
Clin Res Cardiol. 2012 May 15. [Epub ahead of print]

Buss SJ, Mereles D, Emami M, Korosoglou G, Riffel JH, Bertel D, Schonland SO, Hegenbart U, Katus HA, Hardt SE.
Rapid assessment of longitudinal systolic left ventricular function using speckle tracking of the mitral annulus.
Clin Res Cardiol. 2012;101:273-280.

Sommer AP, Bieschke J, Friedrich RP, Zhu D, Wanker EE, Fecht HJ, Mereles D, Hunstein W.
670 nm Laser Light and EGCG Complementarily Reduce Amyloid-ß Aggregates in Human Neuroblastoma Cells: Basis for Treatment of Alzheimer's Disease?
Photomed Laser Surg. 2012;30:54-60.


Mereles D, Hunstein W.
Epigallocatechin-3-gallate (EGCG) for Clinical Trials: More Pitfalls than Promises?
Int J Mol Sci. 2011;12:5592-5603.
open source

Vogel B, Thomas D, Mereles D, Rottbauer W, Katus HA.
Systemic Embolization and Myocardial Infarction due to Clinically Unrecognized Left Atrial Myxoma.
Case Report Med. 2011;2011:159024. Epub 2011 Nov 30.

Buss SJ, Mereles D, Emami M, Korosoglou G, Riffel JH, Bertel D, Schonland SO, Hegenbart U, Katus HA, Hardt SE.
Rapid assessment of longitudinal systolic left ventricular function using speckle tracking of the mitral annulus.
Clin Res Cardiol. 2011 Dec 4. [Epub ahead of print]

Pleger ST, Mereles D, Schulz-Schönhagen M, Krumsdorf U, Chorianopoulos E, Rottbauer W, Katus HA, Bekeredjian R.
Acute safety and 30-day outcome after percutaneous edge-to-edge repair of mitral regurgitation in very high-risk patients.
Am J Cardiol. 2011 Sep 3. [Epub ahead of print]

Bekeredjian R, Mereles D, Pleger S, Krumsdorf U, Katus HA, Rottbauer W.
Large atrial thrombus formation after MitraClip implantation: is anticoagulation mandatory?
J Heart Valve Dis. 2011;20:146-148.

Buss SJ, Mereles D, Katus HA, Hardt SE.
Left ventricular non-compaction cardiomyopathy mimicking an infiltrative cardiac disease.
Int J Cardiol. 2011;147:e41-43.

Barrio JP, Cura G, Ramallo G, Diez M, Vigliano CA, Katus HA, Mereles D.
Heart transplantation in rapidly progressive end-stage heart failure associated with celiac disease.
BMJ Case Reports 2011; doi:10.1136/bcr.12.2010.3624


Konstandin MH, Korosoglou G, Hosch W, Hardt SE, Katus HA, Mereles D.
Severe right ventricular outflow tract obstruction caused by Non-Hodgkin lymphoma: complete regression after one course of bendamustine/rituximab therapy.
J Am Soc Echocardiogr. 2010 Oct 23. [Epub ahead of print]

Korosoglou G, Ehlermann P, Mereles D, Giannitsis E, Katus HA.
Non-compaction cardiomyopathy of the left ventricle diagnosed by cardiac magnetic resonance in a 2-generation family.
Clin Res Cardiol. 2010 Sep 7. [Epub ahead of print]

Hess A, Rottbauer W, Katus HA, Mereles D.
Exaggerated apical trabeculations mimicking left ventricular thrombus: a 3D TEE perspective.
Clinical Research in Cardiology 2010 Jul 1. [Epub ahead of print]

Wolf D, Benz A, Hardt SE, Katus HA, Mereles D.
Trepopnea Associated with Paroxysmal Severe Tricuspid Regurgitation Triggered at Left Lateral Decubitus Position.
Echocardiography 2010 Jun 9. [Epub ahead of print]

Möller T, Brun H, Fredriksen PM, Holmstrøm H, Peersen K, Pettersen E, Grünig E, Mereles D, Thaulow E.
Right ventricular systolic pressure response during exercise in adolescents born with atrial or ventricular septal defect.
The American Journal of Cardiology 2010;105:1610-1616.

Filusch A, Mereles D, Gruenig E, Buss S, Katus HA, Meyer FJ.
Strain and strain rate echocardiography for evaluation of right ventricular dysfunction in patients with idiopathic pulmonary arterial hypertension.
Clinical Research in Cardiololgy 2010 Mar 30. [Epub ahead of print]

Mereles D, Buss SJ, Hardt SE, Hunstein W, Katus HA.
Effects of the main green tea polyphenol epigallocatechin-3-gallate on cardiac involvement in patients with AL amyloidosis.
Clinical Research in Cardiology 2010 Mar 10. [Epub ahead of print]

Hess A, Korosoglou G, Rottbauer W, Katus HA, Mereles D.
Successful treatment of cardiac manifestation of eosinophilic leukemia.
Clinical Research in Cardiology 2010;99:409-410.

Konstandin MH, Hardt SE, Katus HA, Mereles D.
Pronounced coronary artery calcification: Casual finding in transthoracic echocardiography.
International Journal of Cardiology 2009 Nov 5. [Epub ahead of print]

Mayer C, Frank C, Frank D, Tochtermann U, Rehnitz C, Grenacher L, Hardt SE, Katus HA, Mereles D.
Left atrial wall dissection, mitral valve prosthesis dehiscence and pericardial hematoma: complex findings after successful cardiac resuscitation.
Clinical Research in Cardiology 2010;99:57-58.


Grünig E, Weissmann S, Ehlken N, Fijalkowska A, Fischer C, Fourme T, Galié N, Ghofrani A, Harrison RE, Huez S, Humbert M, Janssen B, Kober J, Koehler R, Machado RD, Mereles D, Naeije R, Olschewski H, Provencher S, Reichenberger F, Retailleau K, Rocchi G, Simonneau G, Torbicki A, Trembath R, Seeger W.
Stress Doppler Echocardiography in Relatives of Patients With Idiopathic and Familial Pulmonary Arterial Hypertension. Results of a Multicenter European Analysis of Pulmonary Artery Pressure Response to Exercise and Hypoxia.
Circulation 2009;119:1747-1757.

Bär H, Siegmund A, Wolf D, Hardt S, Katus HA, Mereles D.
Prevalence of asymptomatic mitral valve malformations.
Clinical Research in Cardiology 2009;98:305-309.

Buss SJ, Mereles D, Katus HA, Hardt SE.
Left ventricular non-compaction cardiomyopathy mimicking an infiltrative cardiac disease.
International Journal of Cardiololy 2009 Feb 19. [Epub ahead of print]

Buss SJ, Wolf D, Mereles D, Blank N, Katus HA, Hardt SE.
A rare case of reversible constrictive pericarditis with severe pericardial thickening in a patient with adult onset Still's disease.
International Journal of Cardiology 2009 Jan 29. [Epub ahead of print]

Bär H, Katus HA, Mereles D.
Accessory mitral valve as a potential source of cardioembolism.
International Journal of Cardiology 2009;131:e76-77. Epub 2007 Aug 20.

Bär H, Katus HA, Mereles D.
Unexpected pulsatile intracardiac mass.
International Journal of Cardiology 2009;135:e52-54

Bär H, Katus HA, Mereles D.
Biventricular involvement in transient apical ballooning syndrome.
International Journal of Cardiology 2009;133:e79-80.

Buss SJ, Johanssen C, Katus HA, Mereles D.
A trapped thrombus in the right ventricle.
International Journal of Cardiology 2009;133:e60-61


Hansen A, Mereles D.
Cardiac complications in Whipple's disease.
European Journal of Echocardiography 2008;9:426-427.

Mereles D, Wanker EE, Katus HA.
Therapy effects of green tea in a patient with systemic light-chain amyloidosis.
Clinical Research in Cardiology 2008;97:341-344.

Kasimir MT, Mereles D, Aigner C, Jaksch P, Benz A, Kreuscher S, Klepetko W, Grünig E.
Assessment of pulmonary artery systolic pressures by stress Doppler echocardiography after bilateral lung transplantation.
Journal of Heart and Lung Transplantation 2008;27:66-71.

Möller T, Pettersen E, Peersen K, Fredriksen P, Holmstrøm H, Grünig E, Mereles D, Thaulow E.
Exercise-induced abnormal pulmonary arterial pressure response in adolescents and adults with atrial or ventricular septal defect.
Cardiology in the Young 2008;18:223.


Buss S, Katus HA, Mereles D.
Dynamic changing mass behind the left atrium.
Heart 2007;93:1583.

Buss SJ, Lehrke S, Katus HA, Mereles D.
Deep recessus of the muscular interventricular septum documented with echocardiography and magnetic resonance imaging.
International Journal of Cardiology 2007;120:e30-31.

Reichenberger F, Koester M, Mereles D, Fijalkowska A, Weissmann S, Grunig E, Torbicki A, Olschewski H, Seeger W.
Cardiopulmonary exercise testing for detection of early pulmonary vascular changes in relatives of patients with idiopathic pulmonary arterial hypertension.
European Respiratory Journal 2007;30:S51,250s.

Scholz EP, Zitron E, Katus HA, Karle CA, Mereles D.
Atrial septal aneurysm mimicking ECG signs of enlarged right atrium.
Europace 2007;9:475-476.

Mereles D, Ewert R, Lodziewski S, Borst MM, Benz A, Olschewski H, Grunig E.
Effect of Inhaled Iloprost during Off-Medication Time in Patients with Pulmonary Arterial Hypertension.
Respiration 2007;74:498-502.

Dehnert C, Bartsch P, Grunig E, Mereles D.
High-altitude pulmonary edema and patent foramen ovale.
JAMA 2007;297:1432.

Johanssen C, Mereles D, Hardt S, Buss SJ, Zeier M.
Liquefaction necrosis of mitral annulus calcification in a patient with chronic renal failure: an unrecognized diagnosis.
Clinical Nephrology 2007;67:126-128.

Ley S, Mereles D, Puderbach M, Gruenig E, Schock H, Eichinger M, Ley-Zaporozhan J, Fink C, Kauczor HU.
Value of MR phase-contrast flow measurements for functional assessment of pulmonary arterial hypertension.
European Radiology 2007;17:1892-1897.

Bär H, Mereles D, Libicher M, Katus HA.
Lariat-like sarcoma infiltration of the left atrium.
International Journal of Cardiology 2007;116:e51-52.

Ley S, Mereles D, Risse F, Grunig E, Ley-Zaporozhan J, Tecer Z, Puderbach M, Fink C, Kauczor HU.
Quantitative 3D pulmonary MR-perfusion in patients with pulmonary arterial hypertension: Correlation with invasive pressure measurements.
European Journal of Radiology 2007;61:251-255.


Mereles D, Ehlken N, Kreuscher S, Ghofrani S, Hoeper MM, Halank M, Meyer FJ, Karger G, Buss J, Juenger J, Holzapfel N, Opitz C, Winkler J, Herth FF, Wilkens H, Katus HA, Olschewski H, Grunig E.
Exercise and Respiratory Training Improve Exercise Capacity and Quality of Life in Patients With Severe Chronic Pulmonary Hypertension.
Circulation 2006;114:1482-1489.

Dehnert C, Risse F, Ley S, Kuder TA, Buhmann R, Puderbach M, Menold E, Mereles D, Kauczor HU, Bartsch P, Fink C.
Magnetic Resonance Imaging of Uneven Pulmonary Perfusion in Hypoxia in Humans.
American Journal of Respiratory and Critical Care Medicine 2006;174:1132-1138.

Mereles D, Grunig E.
A Stepwise and Practical Approach to Optimizing Echocardiography in Pulmonary Hypertension.
Advances in Pulmonary Hypertension 2006;5:30-33. Erratum: Figure 3 has a subdivision, Figure 3a and 3b.
open source

Ehlken N, Mereles D, Ghofrani A, Hoeper M, Halank M, Meyer J, Karger G, Wilkens H, Herth F, Olschewski H, Grünig E.
Niedrig dosierte Atem- und Bewegungstherapie verbessert die körperliche Leistungsfähigkeit bei Patienten mit schwerer chronischer pulmonaler Hypertonie.
Pneumologie 2006;60:S19.

Mereles D, Ewert R, Lodziewski S, Borst M, Olschewski H, Grünig E.
Inhalative Therapie mit Iloprost verursacht nachts kein Rebound bei Patienten mit schwerer idiopathischer pulmonaler Hypertonie.
Pneumologie 2006;60:S27-S28.

Kasimir MT, Mereles D, Aigner C, Mazhar S, Jaksch P, Benz A, Kreuscher S, Klepetko W,Grünig E.
Systolischer pulmonalarterieller Druck während Belastung nach bilateraler Lungentransplantation.
Pneumologie 2006;60:S28.


Grünig E, Dehnert C, Mereles D, Koehler R, Olschewski H, Bärtsch P, Janssen B.
Enhanced hypoxic pulmonary vasoconstriction in families of adults or children with idiopathic pulmonary arterial hypertension.
Chest 2005;128:630S-633S.

Blessing E, Rottbauer W, Mereles D, Hosch W, Benz A, Friess H, Autschbach F, Muller M, Stremmel W, Katus H.
Isolated left ventricular noncompaction of the myocardium as a cause of embolic superior mesenteric artery occlusion.
Journal of the American Society of Echocardiography 2005;18:693-695.

Dehnert C, Grünig E, Mereles D, von Lennep N, Bärtsch P.
Identification of individuals susceptible to high-altitude pulmonary oedema at low altitude.
European Respiratory Journal 2005;25:545-551.


Grünig E, Koehler R, Miltenberger-Miltenyi G, Zimmermann R, Gorenflo M, Mereles D, Arnold K, Naust B, Wilkens H, Benz A, Von Hippel A, Ulmer HE, Kübler W, Katus HA, Bartram CR, Schranz D, Janssen B.
Primary pulmonary hypertension in children may have a different genetic background than in adults.
Pediatric Research 2004;56:571-578.


Mereles D, Benz A, Kreuscher S, Aigner C, Mazhar S, Jaksch P, Kasimir M-T, Klepetko W, Katus HA, Grünig E.
Systolischer Pulmonalarteriendruck unter Belastung nach bilateraler Lungentransplantation.
Zeitschrift für Kardiologie 2003;92:105.

Benz A, Mereles D, Arnold K, Abushi A, Kücherer H, Katus HA, Grünig E.
Dopplersonographische Bestimmung des systolischen Pulmonalarteriendruckes unter Belastung: Was sind die Normgrenzen?
Zeitschrift für Kardiologie 2003;92:105-106.

Rindermann M, Grünig E, von Hippel A, Koehler R, Miltenberger-Miltenyi G, Mereles D, Arnold K, Pauciulo M, Nichols W, Olschewski H, Hoeper MM, Winkler J, Katus HA, Kübler A, Bartram CR, Janssen B.
Primary pulmonary hypertension may be a heterogeneous disease with a second locus on chromosome 2q31.
Journal of the American College of Cardiology 2003;41:2237-2244.

Köhler R, Janssen B, von Hippel A, Mereles D, Benz A, Pauciulo M, Nichols W, Katus HA, Grünig E.
Häufigkeit der Mutationen des bone morphogenetic protein receptor 2 Gens bei Patienten mit primärer pulmonaler Hypertonie.
Zeitschrift für Kardiologie 2003;92:336.

Benz A, Mereles D, Katus HA, Kücherer H, Grünig E.
Longitudinale Familienuntersuchung bei familiärer dilatativer Kardiomyopathie.
Zeitschrift für Kardiologie 2003;92:337.

Grünig E, Benz A, Mereles D, Unnebrink K, Kucherer H, Haass M, Kubler W, Katus HA.
Prognostic value of serial cardiac assessment and familial screening in patients with dilated cardiomyopathy.
European Journal of Heart Failure 2003;5:55-62.


Mereles D, Arnold K, Olschewski H, Winkler J, Höper MM, Kübler W, Nichols W, Katus HA, Janssen B, Grünig E.
Frequency of familial primary pulmonary hypertension in a cohort study.
Circulation 2002;106:365.

Rindermann M, Janssen B, von Hippel A, Miltenberger-Miltenyi G, Mereles D, Olschewski H, Benz A, Katus HA, Grünig E.
Primary pulmonary hypertension: genetic heterogeneity and evidence for a second locus on 2q31-32.
Circulation 2002;106:365.

Grünig E, Mereles D, Benz A, Hansen A, Kübler W, Kuecherer H.
Contribution of stress echocardiography to clinical decision making in unselected ambulatory patients with known or suspected coronary artery disease.
International Journal of Cardiology 2002;84:179-185.

Grünig E, Mereles D, Arnold K, Benz A, Olschewski H, Miltenberger-Miltenyi G, Borst MM, Abushi A, Seeger W, Winkler J, Höper MM, Bartram CR, Kübler W, Janssen B.
Primary pulmonary hypertension is predominantly a hereditary disease.
Chest 2002;121:81-82.

Janssen B, Rindermann M, Barth U, Miltenberger-Miltenyi G, Mereles D, Abushi A, Seeger W, Kübler W, Bartram C, Grünig E.
Linkage analysis in a large family with primary pulmonary hypertension: genetic heterogeneity and a second primary pulmonary hypertension locus on 2q31-32.
Chest 2002;121:54-56.

Arnold K, Dehnert C, Mereles D, Miltenberger-Miltenyi G, Rindermann M, Abushi A, Benz A, Kübler W, Bärtsch P, Janssen B, Grünig E.
Abnormale hypoxie Vasokonstriktion bei Genträgern der primären pulmonalen Hypertonie.
Zeitschrift für Kardiologie 2002;91:210.

Grünig E, Miltenberger-Miltenyi G, Mereles D, Arnold K, Benz A, Zimmermann R, Schranz D, Abushi A, Kübler K, Janssen B.
Primäre pulmonale Hypertonie bei Kinder.
Zeitschrift für Kardiologie 2002;91:176.


Grünig E, Mereles D, Dehnert C, Arnold K, Miltenberger-Miltenyi G, Rindermann M, Abushi A, Kübler W, Janssen B, Bärtsch P.
Identification of susceptibility to primary pulmonary hypertension by Doppler-echocardiography during prolonged hypoxia.
Circulation 2001;104:502.

Baer H, Mereles D, Grünig E, Kuecherer H.
Exaggerated pectinate muscles mimicking multiple left atrial appendage thrombi.
European Journal of Echocardiography 2001;2:131.

Hansen A, Mereles D, Kuecherer H.
Echocardiographic diagnosis of Bland-White-Garland syndrome.
Heart 2001;85:152.


Grünig E, Janssen B, Mereles D, Barth U, Borst MM, Vogt IR, Fischer C, Olschewski H, Kuecherer H, Kübler W.
Abnormal pulmonary artery response in asymptomatic carriers of primary pulmonary hypertension gene.
Circulation 2000;102:1145-1150.

Grünig E, Mereles D, Hildebrandt W, Swenson E, Kübler W, Kücherer H, Bärtsch P.
Stress doppler echocardiography for identification of susceptibility for high altitude pulmonary edema.
Journal of the American College of Cardiology 2000;35:980-987.

Viedt C, Mereles D, Kübler W, Kreuzer J.
Fibrinolytic therapy in thrombosis of a mitral valve prothesis.
Zeitschrift für Kardiologie 2000;89:698-701.

Mereles D, Borst M, Barth U, Benz A, Kücherer H, Kübler W, Janssen B, Grünig E.
Identifikation von asymptomatischen Genträgern der familiären primären pulmonalen Hypertonie.
Zeitschrift für Kardiologie 2000;89:45.

Benz A, Mereles D, Borst M, Barth U, Abushi A, Kücherer H, Kübler W, Janssen B, Grünig E.
Prävalenz der familiären primären pulmonalen Hypertonie.
Zeitschrift für Kardiologie 2000;89:45.

Hansen A, Zugck C, Krüger C, Kell R, Unnebrink K, Mereles D, Kücherer H, Haass M.
Risikostratifizierung von Patienten mit chronischer Herzinsuffizienz anhand nichtinvasiver Parameter.
Zeitschrift für Kardiologie 2000;89:58.


Hansen A, Zugck C, Krüger C, Kell R, Hardt S, Mereles D, Haass M, Kuecherer H.
Prognostic value of transmitral flow patterns in patients with chronic congestive heart failure.
European Heart Journal 1999;20:610.

Hansen A, Zugck C, Krueger C, Gerber S, Hardt S, Mereles D, Mura R, Haass M, Kuecherer H.
Prognostic value of Doppler echocardiographic transmitral flow patterns in 191 patients with congestive heart failure.
Journal of the American Society of Echocardiography 1999;12:395.

Grünig E, Ivandic B, Mereles D, Rottbauer W, Benz A, Janssen B, Kübler W.
Identifikation eines Genlokus auf Chromosom 1 in einer Familie mit autosomal verebter DCM und regionalen linksventrikulären Kontraktionsstörungen.
Zeitschrift für Kardiologie 1999;88:250.


Grünig E, Mereles D, Hildebrandt W, Swenson E, Kuecherer H, Elser H, Busch T, Kübler W.
Stress-Echokardiographie zur Identifikation Höhenlungenödem anfälliger Personen.
Zeitschrift für Kardiologie 1998;87:293.

Grünig E, Wurster M, Mereles D, Barth-Witte U, Benz A, Kuecherer H, Katus H, Borst M, Janssen B.
Familiäre primäre pulmonale Hypertonie: Klinische Frühdiagnostik und Kopplungsanalyse in einer großen Familie.
Zeitschrift für Kardiologie 1998;87:240.

Gruenig E, Vogt I, Mereles D, Wurster M, Barth-Witte U, Kübler W, Kuecherer H, Borst M, Janssen B.
Familial primary pulmonary hypertension: early clinical diagnosis and linkage analysis in a large family.
Circulation 1998;98:673.


Grünig E, Benz A, Meyer K, Mereles D, Kübler W, Kuecherer H, Katus HA.
Has the prognosis of dilated cardiomyopathy improved indeed?.
Journal of Heart Failure 1997;4:98.

Mereles D, Grünig E, Katus H, Kübler W, Kuecherer H.
Impact of stress echocardiography on clinical decision making in ambulatory patients with known or suspected coronary artery disease.
European Heart Journal 1997;18:554.

Gruenig E, Mereles D, Hildebrandt W, Swenson E, Kuecherer H, Busch T, Bärtsch P.
Hypertensive pulmonary response to exercise and to hypoxia in subjects with prior high altitude pulmonary edema measured by stress echocardiography.
Circulation 1997;96:427.

Mereles D, Gruenig E, Kuecherer H.
What is the impact of stress echocardiography on clinical decision making?
Circulation 1997;96:387.

Glombitza G, Makabe M, Hardt S, Mereles D, Meinzer H, Kuecherer H, Kübler W.
3-dimensionale Echokardiographie: Vergleich volumetrischer Methoden für rotationsakquirierte Bilddaten.
Zeitschrift für Kardiologie 1997;39:133.

Kuecherer H, Glombitza G, Makabe M, Hardt S, Mereles D, Meinzer H, Kübler W.
3-dimensionale Echokardiographie: In-vitro-Studie zur Anwendung eines neuen volumenorientierten Rekonstruktionsverfahren.
Zeitschrift für Kardiologie 1997;39:147.

1996 - 1989

Frank S, Mereles D, Kücherer H, Kübler W.
Beziehung zwischen Pulmonalvenenfluß und Lebensalter.
Zeitschrift für Kardiologie 1996;85:31.

Mereles D, Hardt S, Kücherer H.
Contrast in echocardiography: diagnostic value in transthoracic and transesophageal examinations.
VI Paraguayan Congress of Cardiology, Asunción, September 1995.

Mereles D.
Clinical value of the interrogation or the pulmonary vein flow during transesophageal echocardiography.
Scientific Session of the Paraguayan Society of Cardiology, October 1994.

Mereles D, Barrios L, Diaz Jure R, Sosa O.
Intravenous diltiazem for acute atrial fibrillation.
Scientific Session of the Paraguayan Society of Cardiology, September 1993.
Published in Anales de la Facultat de Ciencias Médicas, Asunción, Paraguay 1993.

Mereles D, Barrios L.
Dobutamin-Stress-Echocardiography: first experiences in Paraguay.
Scientific Session of the Paraguayan Society of Cardiology, May 1992.

Mereles D, Barrios L, Sosa O.
Intracavitary thombus in dilated cardiomyopathy.
First Paraguayan Congress of Internal Medicine, April 1990.
Scientific Session of the Paraguayan Society of Cardiology, July 1990.

Mereles D, Barrios L, Sosa O.
Familial cardiomyopathy.
Scientific Session of the Paraguayan Society of Cardiology, August 1989.